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Differential gene expression in CD11b+ splenocytes from mice subject to social threat vs. control

ABSTRACT: Gene expression profiling was carried out on splenocyte mRNA samples collected from 10 animals subject to repeated social threat (pooled into 2 groups of 5) and 10 animals subject to non-threatening control conditions (pooled into 2 groups of 5). The primary research question is whether gene expression differs in CD11b+ splenocytes from animals exposed to social threat vs non-threatening control conditions. Keywords: Risk prediction

ORGANISM(S): Mus musculus

PROVIDER: GSE16661 | GEO | 2010/03/31

SECONDARY ACCESSION(S): PRJNA117403

REPOSITORIES: GEO

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Differential gene expression in CD11b+ splenocytes from mice subject to social threat vs. control (II)

2013-12-01 | GSE28830 | GEO

Differential gene expression in CD11b+ splenocytes from mice subject to social threat vs. control (II)

Project description:Gene expression profiling was carried out on splenocyte mRNA samples collected from 6 animals subject to repeated social threat and 6 animals subject to non-threatening control conditions (pooled into 3 groups of 2). The primary research question is whether gene expression differs in CD11b+ splenocytes from animals exposed to social threat vs non-threatening control conditions. Keywords: Risk prediction Gene expression profiling was carried out on splenocyte mRNA samples collected from 6 animals subject to repeated social threat and 6 animals subject to non-threatening control conditions (pooled into 3 groups of 2). The primary research question is whether gene expression differs in CD11b+ splenocytes from animals exposed to social threat vs non-threatening control conditions. This study provides an additional body of data from the same general protocol used in Series GSE16661, and will support more extensive analyses than the original study.

2013-12-01 | E-GEOD-28830 | biostudies-arrayexpress

Differential gene expression in CD11b+ splenocytes from mice subject to social threat vs. control

Project description:Gene expression profiling was carried out on splenocyte mRNA samples collected from 10 animals subject to repeated social threat (pooled into 2 groups of 5) and 10 animals subject to non-threatening control conditions (pooled into 2 groups of 5). The primary research question is whether gene expression differs in CD11b+ splenocytes from animals exposed to social threat vs non-threatening control conditions. Keywords: Risk prediction RNA from 5 mice/sample was pooled to generate 4 total samples: 2 from mice subject to repeated social threat, and 2 from control mice.

2010-04-12 | E-GEOD-16661 | biostudies-arrayexpress

Differential gene expression in prefrontal cortex from mice subject to social threat vs. control

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2010-03-31 | GSE16660 | GEO

Differential gene expression in prefrontal cortex from mice subject to social threat vs. control

2010-04-12 | E-GEOD-16660 | biostudies-arrayexpress

Meningeal immune signaling supports emotional adaptation following threat

Project description:Social creatures must attend to threat signals from conspecifics and respond appropriately, both behaviorally and physiologically. In this work, we show a threat-sensitive immune signaling that orchestrates psychological processes and is amenable to social modulation. Repeated encounters with socially-cued threats triggered neutrophil priming preferentially in males. Meningeal niche-specific neutrophil activity was correlated with attenuated defensive responses to cues. The neutrophil-specific membrane protein CD177 responded to threat-predicting social cues, and its genetic ablation abrogated male behavioral phenotypes. Neutrophil CD177 signaling facilitated optimal meningeal IFN-γ production, which blunted neural response to threatening stimuli by enhancing intrinsic GABAergic inhibition within the prelimbic cortex. Initiation of meningeal neutrophil-mediated IFN-γ signaling was sensitized by negative emotional states and governed by socially dependent androgen release. This male-biased hormone/neutrophil regulatory axis is seemingly conserved in humans. Our findings provide insights into how immune responses influence behavioral responses to threats, suggesting a possible neuroimmune basis of emotional regulation.

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2023-11-01 | GSE241475 | GEO

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2013-11-04 | E-GEOD-47153 | biostudies-arrayexpress

Differential gene expression in lymph nodes from rhesus macaque subject to unstable social condition vs. control

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Differential gene expression in peripheral blood leukocytes from mice subject to repeated social defeat

Project description:This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood mononuclear cells (PBMC), and examined the extent to which these effects were abrogated by depletion of CD11b+ cells (monocytes). Study Type: Risk prediction Gene expression profiling was carried out on peripheral blood mononuclear cell (PBMC) mRNA samples collected from 18 mice randomized to either 6 cycles of repeated social defeat (RSD, n=9) or to home cage control (HCC, n=9) conditions. PBMC samples were pooled into 3 groups of n=3 samples in each condition, and Illumina Mouse Ref-8 BeadArray assays were performed on approximately 1 million total PBMC and 1 million PBMC from which CD11b+ cells were immunomagnetically depleted by MACS. The primary research questions are 1) whether expression of pro-inflammatory genes is altered by RSD, and 2) whether depletion of CD11b+ cells (monocytes) abrogates these effects.

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