Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Plag1 overexpression cooperates with Evi1 overexpression and Gata1s mutation in leading to M7 leukemia

ABSTRACT: The goal of this study is to develop a Plag1 signature and determine how its overexpression contributes to leukemogenesis. To study this, we transduced an immortalized (but not transformed) cell line (derived from Gata1s mutant fetal liver progenitor through insertional mutagenesis) by Plag1-expressing retrovirus. This turned a non-transformed cell line to a leukemogenic cell line. To study whether Plag1 overexpression led to deregulation of signaling pathways that may contribute to leukemic transformation, we generated microarray gene expression profiles of this cell line transduced with either Plag1 or the empty vector. We generated gene expression profiles by microarray from stable cell lines transduced with either the empty vector or the Plag1-expressing vector.

ORGANISM(S): Mus musculus

SUBMITTER: Zhe Li 

PROVIDER: E-GEOD-16679 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis.

Klusmann Jan-Henning JH   Godinho Frank J FJ   Heitmann Kirsten K   Maroz Aliaksandra A   Koch Mia Lee ML   Reinhardt Dirk D   Orkin Stuart H SH   Li Zhe Z  

Genes & development 20100801 15

Oncogene-mediated transformation of hematopoietic cells has been studied extensively, but little is known about the molecular basis for restriction of oncogenes to certain target cells and differential cellular context-specific requirements for oncogenic transformation between infant and adult leukemias. Understanding cell type-specific interplay of signaling pathways and oncogenes is essential for developing targeted cancer therapies. Here, we address the vexing issue of how developmental restr  ...[more]

Similar Datasets

Transcriptomics Plag1 overexpression cooperates with Evi1 overexpression and Gata1s mutation in leading to M7 leukemia
2010-08-01 | GSE16679 | GEO
Transcriptomics Murine M7 leukemia derived from retroviral insertional mutagenesis of Gata1s fetal progenitors depends on IGF signaling
2010-08-01 | E-GEOD-16684 | biostudies-arrayexpress
Transcriptomics Murine M7 leukemia derived from retroviral insertional mutagenesis of Gata1s fetal progenitors
2010-08-01 | E-GEOD-16682 | biostudies-arrayexpress
Transcriptomics KRASG12D Transforms Murine B-Cell Progenitors and Causes Aggressive ALL in Vivo
2024-03-10 | GSE107695 | GEO
Proteomics Characterising early phosphorylation events upon HER2 protein overexpression
2023-01-23 | PXD034105 | Pride
Transcriptomics Rescue of murine Gata1s mutant M7 leukemic cells by full-length Gata1
2010-08-01 | E-GEOD-16676 | biostudies-arrayexpress
Transcriptomics Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during progenitor cell differentiation
2019-03-01 | GSE125493 | GEO
Transcriptomics Evaluation of mRNA expression changes upon TRAF4 mis-expression in HT1376 and T24 bladder cancer cell lines
2020-11-16 | GSE161509 | GEO
Transcriptomics miR-378-3p Knockdown Mimics of MDS
2022-05-20 | GSE175434 | GEO
Transcriptomics Gene expression analysis of HepaRG cells that ectopically express miR-371-3 cluster
2012-12-31 | GSE21080 | GEO