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Undifferentiated Pleomorphic Sarcoma Model

ABSTRACT: Analysis of undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma-like tumors from LSL-KrasG12D, p53Fl/Fl mouse model of soft tissue sarcoma. Murine soft tissue sarcomas (n = 17) were compared to normal muscle (n = 4). Tumors were isolated surgically from soft tissue sarcomas generated by conditional Kras and p53 alleles. Tumors were induced using an adenovirus expressing Cre recombinase. Normal muscle samples were isolated from mice of the same genotype without tumor induction.

ORGANISM(S): Mus musculus

SUBMITTER: Brian Brigman

PROVIDER: E-GEOD-16779 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.

Mito Jeffrey K JK Riedel Richard F RF Dodd Leslie L Lahat Guy G Lazar Alexander J AJ Dodd Rebecca D RD Stangenberg Lars L Eward William C WC Hornicek Francis J FJ Yoon Sam S SS Brigman Brian E BE Jacks Tyler T Lev Dina D Mukherjee Sayan S Kirsch David G DG

PloS one 20091130 11

Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue ...[more]

PMID: 19956606

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Undifferentiated Pleomorphic Sarcoma Model

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