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Trancription profiling of human soft tissue sarcomas: characterization & reclassification of malignant fibrous histiocytoma

ABSTRACT: In soft tissue sarcomas, diagnosis of malignant fibrous histiocytoma (MFH) has been a very controversial issue, and MFH is now considered to be reclassified into pleomorphic subtypes of other sarcomas. To characterize and reclassify MFH genetically, we analyzed gene expression in 105 samples from ten types of soft tissue tumors. Experiment Overall Design: Gene expression of 105 soft tissue tumor samples consisting of synovial sarcoma (n=16), myxoid liposarcoma (n=19), lipoma (n=3), well-differentiated liposarcoma (n=3), dedifferentiated liposarcoma (n=15), myxofibrosarcoma (n=15), leiomyosarcoma (n=6), malignant peripheral nerve sheath tumor (n=3), fibrosarcoma (n=4) and malignant fibrous histiocytoma (n=21) were analyzed using an Affymetrix HG-U133A array.

ORGANISM(S): Homo sapiens

SUBMITTER: Hitoshi Ichikawa 

PROVIDER: E-GEOD-6481 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma.

Nakayama Robert R   Nemoto Takeshi T   Takahashi Hiro H   Ohta Tsutomu T   Kawai Akira A   Seki Kunihiko K   Yoshida Teruhiko T   Toyama Yoshiaki Y   Ichikawa Hitoshi H   Hasegawa Tadashi T  

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20070427 7

In soft tissue sarcomas, the diagnosis of malignant fibrous histiocytoma (MFH) has been a very controversial issue, and MFH is now considered to be reclassified into pleomorphic subtypes of other sarcomas. To characterize MFH genetically, we used an oligonucleotide microarray to analyze gene expression in 105 samples from 10 types of soft tissue tumors. Spindle cell and pleomorphic sarcomas, such as dedifferentiated liposarcoma, myxofibrosarcoma, leiomyosarcoma, malignant peripheral nerve sheath  ...[more]

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