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Hybrid Mouse diversity Panel Liver Expression Profile

ABSTRACT: Novel, systems-based approach to mouse genetics. Expression Profiles from 99 strains of inbred and recombinant inbred mice. Most assayed in triplicate. Two of 288 chips were excluded from the final analysis due to low QC scores.

ORGANISM(S): Mus musculus

SUBMITTER: Brian Bennett

PROVIDER: E-GEOD-16780 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A high-resolution association mapping panel for the dissection of complex traits in mice.

Bennett Brian J BJ Farber Charles R CR Orozco Luz L Kang Hyun Min HM Ghazalpour Anatole A Siemers Nathan N Neubauer Michael M Neuhaus Isaac I Yordanova Roumyana R Guan Bo B Truong Amy A Yang Wen-pin WP He Aiqing A Kayne Paul P Gargalovic Peter P Kirchgessner Todd T Pan Calvin C Castellani Lawrence W LW Kostem Emrah E Furlotte Nicholas N Drake Thomas A TA Eskin Eleazar E Lusis Aldons J AJ

Genome research 20100106 2

Systems genetics relies on common genetic variants to elucidate biologic networks contributing to complex disease-related phenotypes. Mice are ideal model organisms for such approaches, but linkage analysis has been only modestly successful due to low mapping resolution. Association analysis in mice has the potential of much better resolution, but it is confounded by population structure and inadequate power to map traits that explain less than 10% of the variance, typical of mouse quantitative ...[more]

PMID: 20054062

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