Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Luciano Di Croce
PROVIDER: E-GEOD-16891 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Richly Holger H Rocha-Viegas Luciana L Ribeiro Joana Domingues JD Demajo Santiago S Gundem Gunes G Lopez-Bigas Nuria N Nakagawa Tekeya T Rospert Sabine S Ito Takashi T Di Croce Luciano L
Nature 20101201 7327
Covalent modification of histones is fundamental in orchestrating chromatin dynamics and transcription. One example of such an epigenetic mark is the mono-ubiquitination of histones, which mainly occurs at histone H2A and H2B. Ubiquitination of histone H2A has been implicated in polycomb-mediated transcriptional silencing. However, the precise role of the ubiquitin mark during silencing is still elusive. Here we show in human cell lines that ZRF1 (zuotin-related factor 1) is specifically recruit ...[more]