Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Qiang Tian
PROVIDER: E-GEOD-17054 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Majeti Ravindra R Becker Michael W MW Tian Qiang Q Lee Tsung-Lu Michael TL Yan Xiaowei X Liu Rui R Chiang Jung-Hsien JH Hood Leroy L Clarke Michael F MF Weissman Irving L IL
Proceedings of the National Academy of Sciences of the United States of America 20090213 9
We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of LSC, we identified 3,005 differentially expressed genes. Using 2 independent analyses, we identified multiple pathways that are aberrantly regulated in leukemic stem cells compared with normal HSC. Sev ...[more]