Expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Cecilia Lindgren
PROVIDER: E-GEOD-17060 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes.
Herrera Blanca M BM Lockstone Helen E HE Taylor Jennifer M JM Wills Quin F QF Kaisaki Pamela J PJ Barrett Amy A Camps Carme C Fernandez Christina C Ragoussis Jiannis J Gauguier Dominique D McCarthy Mark I MI Lindgren Cecilia M CM
BMC medical genomics 20090818
<h4>Background</h4>MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissues. We sought to establish differences in global miRNA expression in two insulin-target tissues from inbred rats of spontaneously diabetic and normoglycaemic strains.<h4>Methods</h4 ...[more]
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