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HPV-related methylation in Oropharyngeal squamous cell carcinomas (OPSCC)

ABSTRACT: Using MCIp, we enriched highly methylated DNA from a normal mucosa control and from three OPSCC patient subgroups regarding the HPV status: group A, DNA-RNA- (Tu1-Tu5); group B, DNA+RNA- (Tu6-Tu10); group C, DNA+RNA+ (Tu11-Tu15). 3 groups of tumor biopsies, 5 samples each regarding HPV status: DNA-RNA-, DNA+RNA-, DNA+RNA+ and a control sample (normal mucosa from healthy individual): 15 tumor samples/ 1 control sample

ORGANISM(S): Homo sapiens

SUBMITTER: Dr Efterpi Kostareli

PROVIDER: E-GEOD-41152 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas.

Kostareli Efterpi E Holzinger Dana D Bogatyrova Olga O Hielscher Thomas T Wichmann Gunnar G Keck Michaela M Lahrmann Bernd B Grabe Niels N Flechtenmacher Christa C Schmidt Christopher R CR Seiwert Tanguy T Dyckhoff Gerhard G Dietz Andreas A Höfler Daniela D Pawlita Michael M Benner Axel A Bosch Franz X FX Plinkert Peter P Plass Christoph C Weichenhan Dieter D Hess Jochen J

The Journal of clinical investigation 20130501 6

High-risk types of human papilloma virus (HPV) are increasingly associated with oropharyngeal squamous cell carcinoma (OPSCC). Strikingly, patients with HPV-positive OPSCC are highly curable with ionizing radiation and have better survival compared with HPV-negative patients, but the underlying molecular mechanisms remain poorly understood. We applied an array-based approach to monitor global changes in CpG island hypermethylation between HPV-negative and HPV-positive OPSCCs and identified a spe ...[more]

PMID: 23635773

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