Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Boonyaratanakornkit Jim,
PROVIDER: E-GEOD-1709 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Boonyaratanakornkit J B JB Cogoli A A Li C-F CF Schopper T T Pippia P P Galleri G G Meloni M A MA Hughes-Fulford M M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051006 14
Returning astronauts have experienced altered immune function and increased vulnerability to infection during spaceflights dating back to Apollo and Skylab. Lack of immune response in microgravity occurs at the cellular level. We analyzed differential gene expression to find gravity-dependent genes and pathways. We found inhibited induction of 91 genes in the simulated freefall environment of the random positioning machine. Altered induction of 10 genes regulated by key signaling pathways was ve ...[more]