Gene Expression upon Doxorubicin Treatments
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: ASHUTOSH CHILKOTI
PROVIDER: E-GEOD-17115 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection.
MacKay J Andrew JA Chen Mingnan M McDaniel Jonathan R JR Liu Wenge W Simnick Andrew J AJ Chilkoti Ashutosh A
Nature materials 20091108 12
New strategies to self-assemble biocompatible materials into nanoscale, drug-loaded packages with improved therapeutic efficacy are needed for nanomedicine. To address this need, we developed artificial recombinant chimeric polypeptides (CPs) that spontaneously self-assemble into sub-100-nm-sized, near-monodisperse nanoparticles on conjugation of diverse hydrophobic molecules, including chemotherapeutics. These CPs consist of a biodegradable polypeptide that is attached to a short Cys-rich segme ...[more]
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