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Expression data from YAP-S127D DLD1 Xenografts

ABSTRACT: We overexpressed YAP-S127D in DLD1 colorectal cancer cells for 21 days after sub-cutaneous (SubQ) injection into the flanks of nude mice. Mice were given dox for 21 days, sacrificed, and tumors were isolated for RNA extraction and analyzed by Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Fernando Camargo 

PROVIDER: E-GEOD-41508 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A remarkable feature of regenerative processes is their ability to halt proliferation once an organ's structure has been restored. The Wnt signalling pathway is the major driving force for homeostatic self-renewal and regeneration in the mammalian intestine. However, the mechanisms that counterbalance Wnt-driven proliferation are poorly understood. Here we demonstrate in mice and humans that yes-associated protein 1 (YAP; also known as YAP1)--a protein known for its powerful growth-inducing and  ...[more]

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