Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Javier De Las Rivas
PROVIDER: E-GEOD-17157 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20131231 12
<h4>Background</h4>Insulin-like Growth Factor 1 (IGF1) is a multifunctional regulator of somatic growth and development throughout evolution. IGF1 signaling through IGF type 1 receptor (IGF1R) controls cell proliferation, survival and differentiation in multiple cell types. IGF1 deficiency in mice disrupts lung morphogenesis, causing altered prenatal pulmonary alveologenesis. Nevertheless, little is known about the cellular and molecular basis of IGF1 activity during lung development.<h4>Methods ...[more]