Transcriptomics

Dataset Information

0

Expression data from E18.5 Igf1 -/- (homozygous mutant) and Igf1+/+ (normal wild type control) mouse lungs


ABSTRACT: Insight into the role of Insulin-like Growth Factor (IGF) in development of lungs has come from the study of genetically modified mice. IGF1 is a key factor during lung development. IGF1 deficiency in the neonatal mouse causes respiratory failure collapsed alveoli and altered alveolar septa. To further characterize IGF1 function during lung development we analyzed Igf1-/- mouse prenatal lungs in a C57Bl/6 genetic background. Mutant lungs showed disproportional hypoplasia, disorganized extracellular matrix and dilated alveolar capillaries. IGF1 target genes during lung maturation were identified by analyzing RNA differential expression in Igf1-/- lungs using microarrays.

ORGANISM(S): Mus musculus

PROVIDER: GSE17157 | GEO | 2014/03/31

SECONDARY ACCESSION(S): PRJNA119771

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-03-31 | E-GEOD-17157 | biostudies-arrayexpress
2019-06-27 | GSE133380 | GEO
2013-11-26 | E-GEOD-41413 | biostudies-arrayexpress
2013-09-03 | E-GEOD-41412 | biostudies-arrayexpress
2013-11-26 | GSE41413 | GEO
2013-09-03 | GSE41412 | GEO
2022-11-18 | GSE215089 | GEO
2012-07-31 | E-GEOD-32936 | biostudies-arrayexpress
2015-12-08 | E-GEOD-73861 | biostudies-arrayexpress
2017-06-25 | GSE82158 | GEO