Transcription profiling of mouse EGFR mutants
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: William Pao
PROVIDER: E-GEOD-17373 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
Regales Lucia L Gong Yixuan Y Shen Ronglai R de Stanchina Elisa E Vivanco Igor I Goel Aviva A Koutcher Jason A JA Spassova Maria M Ouerfelli Ouathek O Mellinghoff Ingo K IK Zakowski Maureen F MF Politi Katerina A KA Pao William W
The Journal of clinical investigation 20090914 10
EGFR is a major anticancer drug target in human epithelial tumors. One effective class of agents is the tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. These drugs induce dramatic responses in individuals with lung adenocarcinomas characterized by mutations in exons encoding the EGFR tyrosine kinase domain, but disease progression invariably occurs. A major reason for such acquired resistance is the outgrowth of tumor cells with additional TKI-resistant EGFR mutations. Here w ...[more]
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