Proteome-wide map of targets of T790M-EGFR-directed covalent inhibitors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Lung, Liver
DISEASE(S): Non-small Cell Lung Carcinoma
SUBMITTER: 
Melissa Dix
LAB HEAD: Benjamin F. Cravatt
PROVIDER: PXD007163 | Pride | 2019-11-11
REPOSITORIES: Pride
Dataset's files
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| DCG04_Liver_N1_01.raw | Raw | |||
| DCG04_Liver_N1_02.raw | Raw | |||
| DCG04_Liver_N1_03.raw | Raw | |||
| DCG04_Liver_N1_04.raw | Raw | |||
| DCG04_Liver_N1_05.raw | Raw |
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Publications
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.
Niessen Sherry S Dix Melissa M MM Barbas Sabrina S Potter Zachary E ZE Lu Shuyan S Brodsky Oleg O Planken Simon S Behenna Douglas D Almaden Chau C Gajiwala Ketan S KS Ryan Kevin K Ferre RoseAnn R Lazear Michael R MR Hayward Matthew M MM Kath John C JC Cravatt Benjamin F BF
Cell chemical biology 20170928 11
Patients with non-small cell lung cancers that have kinase-activating epidermal growth factor receptor (EGFR) mutations are highly responsive to first- and second-generation EGFR inhibitors. However, these patients often relapse due to a secondary, drug-resistant mutation in EGFR whereby the gatekeeper threonine is converted to methionine (T790M). Several third-generation EGFR inhibitors have been developed that irreversibly inactivate T790M-EGFR while sparing wild-type EGFR, thus reducing epith ...[more]
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