Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Microarray analysis to identify the molecular mechanisms whereby pDCs confer growth and drug resistance in MM cells


ABSTRACT: Multiple Myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. We performed microarray analysis to identify the molecular mechanisms whereby pDCs confer growth and drug resistance in MM cells. Comparsion of MM cells in the presence and absence of pDCs (plasmacytoid dendritic cells)

ORGANISM(S): Homo sapiens

SUBMITTER: BIDMC Genomics 

PROVIDER: E-GEOD-17407 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Multiple myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. Using both in vitro and in vivo MM xenograft models, we show that plasmacytoid dendritic cells (pDCs) in the bone marrow (BM) microenvironment both mediate immune deficiency characteristic of MM and promote MM cell growth, survival, and drug resistance. Microarray, cell signaling, cytokine profile, and immunohistochemical analysis  ...[more]

Similar Datasets

2009-07-31 | GSE17407 | GEO
2023-08-18 | GSE240978 | GEO
2022-05-27 | GSE197212 | GEO
2008-12-01 | E-GEOD-12218 | biostudies-arrayexpress
2013-09-30 | E-GEOD-49859 | biostudies-arrayexpress
2014-07-25 | E-GEOD-59731 | biostudies-arrayexpress
2014-07-25 | GSE59731 | GEO
2013-09-30 | GSE49859 | GEO
2019-08-22 | GSE131633 | GEO
2022-07-31 | E-MTAB-11933 | biostudies-arrayexpress