Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Claudia Gebhard
PROVIDER: E-GEOD-17455 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gebhard Claudia C Benner Chris C Ehrich Mathias M Schwarzfischer Lucia L Schilling Elmar E Klug Maja M Dietmaier Wolfgang W Thiede Christian C Holler Ernst E Andreesen Reinhard R Rehli Michael M
Cancer research 20100209 4
Aberrant DNA methylation at CpG islands is thought to contribute to cancer initiation and progression, but mechanisms that establish and maintain DNA methylation status during tumorigenesis or normal development remain poorly understood. In this study, we used methyl-CpG immunoprecipitation to generate comparative DNA methylation profiles of healthy and malignant cells (acute leukemia and colorectal carcinoma) for human CpG islands across the genome. While searching for sequence patterns that ch ...[more]