Unknown,Transcriptomics,Genomics,Proteomics

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Analysis of polyploidy-associated transcriptional gene silencing (paTGS) mutants


ABSTRACT: A case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis plants, created an epiallele resistant to many mutations or inhibitor treatments that activate other suppressed genes. This raised the question about the molecular basis of this extreme stability. A combination of forward and reverse genetics, transcriptome profiling and drug application provides evidence for a double safeguard system that is only alleviated upon the simultaneous removal of both DNA methylation and histone methylation by loss of DDM1 or HOG1 acitivity. Three biological replicates per line are provided. C2S1 = Wt line; hog1-7=774; ddm1-12=1135

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Tuncay Baubec 

PROVIDER: E-GEOD-17496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic States in Arabidopsis.

Baubec Tuncay T   Dinh Huy Q HQ   Pecinka Ales A   Rakic Branislava B   Rozhon Wilfried W   Wohlrab Bonnie B   von Haeseler Arndt A   Mittelsten Scheid Ortrun O  

The Plant cell 20100122 1


Epigenetic changes of gene expression can potentially be reversed by developmental programs, genetic manipulation, or pharmacological interference. However, a case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis thaliana plants, created an epiallele resistant to many mutations or inhibitor treatments that activate many other suppressed genes. This raised the question about the molecular basis of this extreme stability. A combination of forward and reverse genetic  ...[more]

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