Melanoma short-term cultures and cell lines: expression profiling and CNV analyses
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael Berger
PROVIDER: E-GEOD-17593 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Integrative analysis of the melanoma transcriptome.
Berger Michael F MF Levin Joshua Z JZ Vijayendran Krishna K Sivachenko Andrey A Adiconis Xian X Maguire Jared J Johnson Laura A LA Robinson James J Verhaak Roel G RG Sougnez Carrie C Onofrio Robert C RC Ziaugra Liuda L Cibulskis Kristian K Laine Elisabeth E Barretina Jordi J Winckler Wendy W Fisher David E DE Getz Gad G Meyerson Matthew M Jaffe David B DB Gabriel Stacey B SB Lander Eric S ES Dummer Reinhard R Gnirke Andreas A Nusbaum Chad C Garraway Levi A LA
Genome research 20100223 4
Global studies of transcript structure and abundance in cancer cells enable the systematic discovery of aberrations that contribute to carcinogenesis, including gene fusions, alternative splice isoforms, and somatic mutations. We developed a systematic approach to characterize the spectrum of cancer-associated mRNA alterations through integration of transcriptomic and structural genomic data, and we applied this approach to generate new insights into melanoma biology. Using paired-end massively ...[more]
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