Transcriptional effect of aft1 and aft2 mutation in iron depleted conditions
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ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Pierre-Louis Blaiseau
PROVIDER: E-GEOD-1763 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1.
Courel Maïté M Lallet Sylvie S Camadro Jean-Michel JM Blaiseau Pierre-Louis PL
Molecular and cellular biology 20050801 15
The yeast Saccharomyces cerevisiae contains a pair of paralogous iron-responsive transcription activators, Aft1 and Aft2. Aft1 activates the cell surface iron uptake systems in iron depletion, while the role of Aft2 remains poorly understood. This study compares the functions of Aft1 and Aft2 in regulating the transcription of genes involved in iron homeostasis, with reference to the presence/absence of the paralog. Cluster analysis of DNA microarray data identified the classes of genes regulate ...[more]
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