Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Tracy Ferea
PROVIDER: E-GEOD-4196 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shakoury-Elizeh Minoo M Tiedeman John J Rashford Jared J Ferea Tracey T Demeter Janos J Garcia Emily E Rolfes Ronda R Brown Patrick O PO Botstein David D Philpott Caroline C CC
Molecular biology of the cell 20031210 3
The budding yeast Saccharomyces cerevisiae responds to depletion of iron in the environment by activating Aft1p, the major iron-dependent transcription factor, and by transcribing systems involved in the uptake of iron. Here, we have studied the transcriptional response to iron deprivation and have identified new Aft1p target genes. We find that other metabolic pathways are regulated by iron: biotin uptake and biosynthesis, nitrogen assimilation, and purine biosynthesis. Two enzymes active in th ...[more]