Transcription profiling of human gastrointestinal stromal tumours according to KIT mutations and expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Krzysztof Goryca
PROVIDER: E-GEOD-17743 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Functional features of gene expression profiles differentiating gastrointestinal stromal tumours according to KIT mutations and expression.
Ostrowski Jerzy J Polkowski Marcin M Paziewska Agnieszka A Skrzypczak Magdalena M Goryca Krzysztof K Rubel Tymon T Kokoszyñska Katarzyna K Rutkowski Piotr P Nowecki Zbigniew I ZI Vel Dobosz Anna Jerzak AJ Jarosz Dorota D Ruka Wlodzimierz W Wyrwicz Lucjan S LS
BMC cancer 20091127
<h4>Background</h4>Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in KIT or PDGFRA of the type III receptor tyrosine kinase family. Although mutations in either receptor are thought to drive an early oncogenic event through similar pathways, two previous studies reported the mutation-specific gene expression profiles. However, their further conclusions were rather discordant. To clarify the mol ...[more]
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