Unknown,Transcriptomics,Genomics,Proteomics

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Control HepG2 vs miR-24 HepG2 cells

ABSTRACT: miR-24 targets were identified in this study using mRNA microarrays. Combined with Bioinformatics, our results show that miR-24 regulates cell cycle and DNA repair. Total RNA was isolated from C or miR-24 over-expressing HepG2 cells after 48 hr of transfection and microarray analysis was performed

ORGANISM(S): Homo sapiens

SUBMITTER: Ashish Lal 

PROVIDER: E-GEOD-17828 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.

Lal Ashish A   Navarro Francisco F   Maher Christopher A CA   Maliszewski Laura E LE   Yan Nan N   O'Day Elizabeth E   Chowdhury Dipanjan D   Dykxhoorn Derek M DM   Tsai Perry P   Hofmann Oliver O   Becker Kevin G KG   Gorospe Myriam M   Hide Winston W   Lieberman Judy J  

Molecular cell 20090901 5

miR-24, upregulated during terminal differentiation of multiple lineages, inhibits cell-cycle progression. Antagonizing miR-24 restores postmitotic cell proliferation and enhances fibroblast proliferation, whereas overexpressing miR-24 increases the G1 compartment. The 248 mRNAs downregulated upon miR-24 overexpression are highly enriched for DNA repair and cell-cycle regulatory genes that form a direct interaction network with prominent nodes at genes that enhance (MYC, E2F2, CCNB1, and CDC2) o  ...[more]

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