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Nkx2.5 regulates Jarid2 during outflow tract morphogenesis

ABSTRACT: The transcription factor Nkx2.5 is required for specification of pharyngeal arch second heart field (SHF) progenitors that contribute to outflow tract (OFT) and right ventricle (RV) formation. Multiple sets of microarray data were analyzed to identify genes that are candidate targets of Nkx2.5 in the second heart field. These sets are: 1) publicly available data for cardiothoracic tissue from E9.5 Nkx2.5 wild-type, heterozygous and homozygous embryos; 2) an analysis of mouse E10.5 pharyngeal arch tissue; 3) an analysis of mouse E12.5 heart tissue; and 4) a temporal analysis of the cardiogenic cell line P19CL6. This combined analysis identified 11 genes (Lrrn1, Elovl2, Safb, Slc39a6, Khdrbs1, Hoxb4, Fez1, Ccdc117, Jarid2, Nrcam, and Enpp3) expressed in SHF-containing pharyngeal arch tissue whose regulation is dependent on Nkx2.5 expression. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Jeremy Barth 

PROVIDER: E-GEOD-17936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis.

Barth Jeremy L JL   Clark Christopher D CD   Fresco Victor M VM   Knoll Ellen P EP   Lee Benjamin B   Argraves W Scott WS   Lee Kyu-Ho KH  

Developmental dynamics : an official publication of the American Association of Anatomists 20100701 7

Nkx2.5, a transcription factor implicated in human congenital heart disease, is required for regulation of second heart field (SHF) progenitors contributing to outflow tract (OFT). Here, we define a set of genes (Lrrn1, Elovl2, Safb, Slc39a6, Khdrbs1, Hoxb4, Fez1, Ccdc117, Jarid2, Nrcam, and Enpp3) expressed in SHF containing pharyngeal arch tissue whose regulation is dependent on Nkx2.5. Further investigation shows that Jarid2, which has been implicated in OFT morphogenesis, is a direct target  ...[more]

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