Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jeremy Barth
PROVIDER: E-GEOD-17934 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Developmental dynamics : an official publication of the American Association of Anatomists 20100701 7
Nkx2.5, a transcription factor implicated in human congenital heart disease, is required for regulation of second heart field (SHF) progenitors contributing to outflow tract (OFT). Here, we define a set of genes (Lrrn1, Elovl2, Safb, Slc39a6, Khdrbs1, Hoxb4, Fez1, Ccdc117, Jarid2, Nrcam, and Enpp3) expressed in SHF containing pharyngeal arch tissue whose regulation is dependent on Nkx2.5. Further investigation shows that Jarid2, which has been implicated in OFT morphogenesis, is a direct target ...[more]