Transcription profiling of heart left ventricles from 15 week old inbred COP, DA, and F1(COP x DA) offspring with respect to aerobic running capacity (low, high, and intermediate performers respectively)
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ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Justin Ways
PROVIDER: E-GEOD-1795 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profiling of the left ventricles in a rat model of intrinsic aerobic running capacity.
Lee Soon Jin SJ Ways Justin A JA Barbato John C JC Essig David D Pettee Krista K DeRaedt Sarah J SJ Yang Siming S Weaver David A DA Koch Lauren G LG Cicila George T GT
Physiological genomics 20050720 1
Our previous work found DA rats superior for intrinsic aerobic running capacity (ARC) and several cardiac function indexes compared with Copenhagen (COP) rats, and identified ARC quantitative trait loci (QTLs) on rat chromosomes 16 (RNO16) and 3 (RNO3). The purpose of this study was to use these inbred rat strains as a genetic substrate for differential cardiac gene expression to identify candidate genes for the observed ARC QTLs. RNA expression was examined globally in left ventricles of 15-wk- ...[more]
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