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ZBTB32 Is an Early Repressor of the CIITA MHC Class II Gene Expression during B Cell Differentiation to Plasma Cells

ABSTRACT: Primary murine B cells were stimulated with IL2, IL5, LPS to induce B cell differentiation for 24 hours. RNA was extracted from control and differentiated B cell to compare gene expression. Murine B cells (CD43-) were purfied from 5 weeks old mice splenocytes. And purified B cells were stimulated with IL2, IL5, LPS for 24 hours.

ORGANISM(S): Mus musculus

SUBMITTER: Jeremy Boss 

PROVIDER: E-GEOD-17999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.

Yoon Hye Suk HS   Scharer Christopher D CD   Majumder Parimal P   Davis Carl W CW   Butler Royce R   Zinzow-Kramer Wendy W   Skountzou Ioanna I   Koutsonanos Dimitrios G DG   Ahmed Rafi R   Boss Jeremy M JM  

Journal of immunology (Baltimore, Md. : 1950) 20120730 5

CIITA and MHC class II expression is silenced during the differentiation of B cells to plasma cells. When B cell differentiation is carried out ex vivo, CIITA silencing occurs rapidly, but the factors contributing to this event are not known. ZBTB32, also known as repressor of GATA3, was identified as an early repressor of CIITA in an ex vivo plasma cell differentiation model. ZBTB32 activity occurred at a time when B lymphocyte-induced maturation protein-1 (Blimp-1), the regulator of plasma cel  ...[more]

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