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Transcription profiling of TGF beta induced cell cycle arrest of human CD34+ hematopoietic cells

ABSTRACT: TGFbeta regulated genes in human umbilical cord blood CD34+ cells

ORGANISM(S): Homo sapiens

SUBMITTER: Agnes Viale

PROVIDER: E-GEOD-1802 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

Scandura Joseph M JM Boccuni Piernicola P Massagué Joan J Nimer Stephen D SD

Proceedings of the National Academy of Sciences of the United States of America 20041011 42

Transforming growth factor beta (TGFbeta) is one of few known negative regulators of hematopoiesis, yet the mechanisms by which it affects cell cycle arrest and stem cell quiescence are poorly understood. Induction of the cyclin-dependent kinase inhibitors, p15INK4b (p15) and p21WAF1 (p21) is important for TGFbeta-mediated cytostasis in epithelial cells but not in hematopoietic cells. Using primary human hematopoietic cells and microarray analysis, we identified p57KIP2 (p57) as the only cyclin- ...[more]

PMID: 15477587

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