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Comparative genome hybridization of meningococcal isolates using 1 color microarray

ABSTRACT: Meningococcal strains from different serogroups and different clonal complexes were compared using cGH analyses in a one color experiment. DNA isolated from the various strains were compared using a single color microarray.

ORGANISM(S): Neisseria meningitidis

SUBMITTER: Biju Joseph

PROVIDER: E-GEOD-18159 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Evaluation of one- and two-color gene expression arrays for microbial comparative genome hybridization analyses in routine applications.

Schwarz Roland R Joseph Biju B Gerlach Gabriele G Schramm-Glück Anja A Engelhard Kathrin K Frosch Matthias M Müller Tobias T Schoen Christoph C

Journal of clinical microbiology 20100630 9

DNA microarray technology has already revolutionized basic research in infectious diseases, and whole-genome sequencing efforts have allowed for the fabrication of tailor-made spotted microarrays for an increasing number of bacterial pathogens. However, the application of microarrays in diagnostic microbiology is currently hampered by the high costs associated with microarray experiments and the specialized equipment needed. Here, we show that a thorough bioinformatic postprocessing of the micro ...[more]

PMID: 20592156

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