Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Characterization of ST-4821 complex, a unique Neisseria meningitidis clone


ABSTRACT: Neisseria meningitidis is the leading cause of bacterial meningitis and septicemia worldwide. The novel ST-4821 clonal complex caused several serogroup C meningococcal outbreaks unexpectedly during 2003–2005 in China. We fabricated a whole-genome microarray of Chinese N. meningitidis serogroup C representative isolate 053442 and characterized 27 ST-4821 complex isolates which were isolated from different serogroups using comparative genomic hybridization (CGH) analysis. This paper provides important clues which are helpful to understand the genome composition and genetic background of different serogroups isolates, and possess significant meaning to the study of the newly emerged hyperinvasive lineage. To further understand the genome diversity of ST-4821 complex isolates, CGH analysis was employed to compare the genomic content of 053442 with those of 27 ST-4821 complex isolates which were isolated from 14 provinces of China during 1977–2005.

ORGANISM(S): Neisseria meningitidis

SUBMITTER: Junping Peng 

PROVIDER: E-GEOD-7780 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Ten outbreaks of a new serogroup C meningococcal disease emerged during 2003-2005 in China. The multilocus sequence typing results indicated that unique sequence type 4821 clone meningococci were responsible for these outbreaks. Herein, we determined the entire genomic DNA sequence of serogroup C isolate 053442, which belongs to ST-4821. Comparison of 053442 gene contents with other meningococcal genomes shows that they have similar characteristics, including thousands of repetitive elements and  ...[more]

Similar Datasets

2007-10-10 | E-GEOD-7331 | biostudies-arrayexpress
2007-11-28 | GSE7780 | GEO
2007-10-11 | GSE7331 | GEO
2007-04-04 | E-TIGR-129 | biostudies-arrayexpress
2019-02-28 | PXD010505 | Pride
2012-06-15 | E-MEXP-3255 | biostudies-arrayexpress
2011-02-11 | GSE20643 | GEO
2012-06-15 | E-MEXP-3258 | biostudies-arrayexpress
2016-05-18 | PXD001498 | Pride
| PRJNA890591 | ENA