Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Martin Sebastian Staege
PROVIDER: E-GEOD-1823 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pediatric blood & cancer 20040701 1
<h4>Background</h4>Interleukin-2 (IL-2) is a potent cytokine with potential activity against several tumors including Ewing tumors (ET). Side effects of systemic IL-2 can be circumvented by the use of transgenic tumor cells. However, in vitro manipulation may change the overall gene expression profile of tumor cells unfavorably. Therefore, we assessed gene expression profiles, safety, and immunomodulatory efficacy of IL-2 transgenic (IL-2-tg) ET cells in vitro and in NOD/scid mice.<h4>Procedure< ...[more]