Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Pengfei Wang
PROVIDER: E-GEOD-18258 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Pengfei P Lin Chengqi C Smith Edwin R ER Guo Hong H Sanderson Brian W BW Wu Min M Gogol Madelaine M Alexander Tara T Seidel Christopher C Wiedemann Leanne M LM Ge Kai K Krumlauf Robb R Shilatifard Ali A
Molecular and cellular biology 20090824 22
A common landmark of activated genes is the presence of trimethylation on lysine 4 of histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is the only H3K4 methylase in Saccharomyces cerevisiae; however, in mammals, at least six H3K4 methylases, Set1A and Set1B and MLL1 to MLL4, are found in COMPASS-like complexes capable of methylating H3K4. To gain further insight into the different roles and functional targets for the H3K4 methylases, we have undertaken a genome-wid ...[more]