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FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

ABSTRACT: FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis expression profile between six independant neural stem cell lines (three FoxO null and three wild type) were compared

ORGANISM(S): Mus musculus

SUBMITTER: Haoqiang Ying

PROVIDER: E-GEOD-18308 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.

Paik Ji-hye JH Ding Zhihu Z Narurkar Rujuta R Ramkissoon Shakti S Muller Florian F Kamoun Walid S WS Chae Sung-Suk SS Zheng Hongwu H Ying Haoqiang H Mahoney Jed J Hiller David D Jiang Shan S Protopopov Alexei A Wong Wing H WH Chin Lynda L Ligon Keith L KL DePinho Ronald A RA

Cell stem cell 20091101 5

The PI3K-AKT-FoxO pathway is integral to lifespan regulation in lower organisms and essential for the stability of long-lived cells in mammals. Here, we report the impact of combined FoxO1, 3, and 4 deficiencies on mammalian brain physiology with a particular emphasis on the study of the neural stem/progenitor cell (NSC) pool. We show that the FoxO family plays a prominent role in NSC proliferation and renewal. FoxO-deficient mice show initial increased brain size and proliferation of neural pro ...[more]

PMID: 19896444

Similar Datasets

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

Project description:FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

2010-01-01 | GSE18308 | GEO

Mus musculus

Project description:FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

| PRJNA118039 | ENA

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.

Project description:The PI3K-AKT-FoxO pathway is integral to lifespan regulation in lower organisms and essential for the stability of long-lived cells in mammals. Here, we report the impact of combined FoxO1, 3, and 4 deficiencies on mammalian brain physiology with a particular emphasis on the study of the neural stem/progenitor cell (NSC) pool. We show that the FoxO family plays a prominent role in NSC proliferation and renewal. FoxO-deficient mice show initial increased brain size and proliferation of neural progenitor cells during early postnatal life, followed by precocious significant decline in the NSC pool and accompanying neurogenesis in adult brains. Mechanistically, integrated transcriptomic, promoter, and functional analyses of FoxO-deficient NSC cultures identified direct gene targets with known links to the regulation of human brain size and the control of cellular proliferation, differentiation, and oxidative defense. Thus, the FoxO family coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain.

| S-EPMC3285492 | biostudies-literature

HUVEC 3xHA.FoxO3.A3.ER +4-OHT vs vector +4-OHT

Project description:Forkhead Box O (FoxO) transcription factors are conserved proteins involved in the regulation of life span and age-related diseases, such as diabetes and cancer. Stress stimuli or growth factor deprivation promote nuclear localization and activation of FoxO proteins, which - depending on the cellular context - leads to cell cycle arrest or apoptosis. Moreover, FoxOs can control oxidative stress resistance and cell metabolism. In endothelial cells (ECs), they additionally regulate angiogenesis and may promote inflammation and vessel destabilization implicating a role of FoxOs in vascular diseases. In several cancers, FoxO transcription factors exert a tumor-suppressive function, due to their critical role in regulating proliferation and survival. Others and we have previously shown that FoxOs can regulate these processes via two different mechanisms: either by direct binding to FoxO-responsive elements (FRE) at the promoter of target genes or by a poorly understood alternative process that does not require direct DNA binding and regulates key targets in primary human ECs. Here we performed an interaction study in ECs to identify new nuclear FoxO3 interaction partners, which might contribute to FoxO-dependent gene regulation. Mass spectrometry analysis of FoxO3-interacting proteins revealed Transformation/Transcription Domain-Associated Protein (TRRAP), a member of multiple histone acetyltransferase (HAT) complexes, as novel binding partner of FoxO family proteins. TRRAP is required to support FoxO3 transactivation and FoxO3-dependent apoptosis in ECs via transcriptional activation of the proapoptotic Bcl-2 family member BIM. Moreover, FoxO-TRRAP interaction might explain FoxO-induced alternative gene regulation via TRRAP-dependent recruitment to target promoters lacking FRE sequences.

2022-01-20 | PXD027615 | Pride

MHOR002 expression: Forkhead box O transcription factors both suppress and support breast cancer progression.

Project description:FOXOs are regulators of cellular homeostasis and putative tumor suppressors. The role of FOXOs in cancer progression remains to be determined however as the data on FOXO function in cancer are fragmentary and come from studies that focused on isolated aspects of cancer, especially for epithelial cancers. To clarify the role of FOXOs in epithelial cancer progression we characterized the effects of inducible FOXO activation and loss in a mouse model of metastatic invasive lobular carcinoma. Strikingly, either activation or loss of FOXO function suppresses tumor growth and metastasis. We show that the multitude of cellular processes critically affected by FOXO function including proliferation, survival, redox homeostasis and PI3K-signaling need to be carefully balanced for tumor cells to thrive.

2018-02-11 | GSE108842 | GEO

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

Project description:Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting genetic analysis of the role of FoxOs in the neoplastic phenotypes linked to PI3K-AKT activation. While germline or somatic deletion of up to five FoxO alleles produced remarkably modest neoplastic phenotypes, broad somatic deletion of all FoxOs engendered a progressive cancer-prone condition characterized by thymic lymphomas and hemangiomas, demonstrating that the mammalian FoxOs are indeed bona fide tumor suppressors. Transcriptome and promoter analyses of differentially affected endothelium identified direct FoxO targets and revealed that FoxO regulation of these targets in vivo is highly context-specific, even in the same cell type. Functional studies validated Sprouty2 and PBX1, among others, as FoxO-regulated mediators of endothelial cell morphogenesis and vascular homeostasis.

2011-03-16 | GSE27932 | GEO

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress

Foxo1/3-deficient Treg cells

Project description:Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell signature genes and genes in control of T cell homeostasis, signaling and metabolism.

2010-09-13 | GSE21678 | GEO

Foxo1/3-deficient Treg cells

2010-09-13 | E-GEOD-21678 | biostudies-arrayexpress

Genome wide analysis of FOXO3 transcription regulation through RNA pol II profiling

Project description:FOXO transcription factors are key players in diverse cellular processes affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into mechanisms of FOXO regulated target gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II changes shows FOXO3 regulates gene expression through transcription initiation. Correlative analysis of FOXO3 and RNA polymerase II ChIP-seq profiles demonstrates FOXO3 to act as a transcriptional activator. Furthermore, this analysis reveals a significant part of FOXO3 gene regulation proceeds through enhancer regions. FOXO3 binds to pre-existing enhancers and further activates these enhancers as shown by changes in histone acetylation and RNA polymerase II recruitment. In addition, FOXO3-mediated enhancer activation correlates with regulation of adjacent genes and pre-existence of chromatin loops between FOXO3 bound enhancers and target genes. Combined, our data elucidate how FOXOs regulate gene transcription and provide insight into mechanisms by which FOXOs can induce different gene expression programs depending on chromatin architecture. Paper with published gene expression: PMID 22139133. Examination of FOXO3 binding and changes in RNAPII occupancy (0, 4, 24 hours after induction) in colorectal cell line

2012-11-15 | E-GEOD-35486 | biostudies-arrayexpress

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