MHOR002 expression: Forkhead box O transcription factors both suppress and support breast cancer progression.
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ABSTRACT: FOXOs are regulators of cellular homeostasis and putative tumor suppressors. The role of FOXOs in cancer progression remains to be determined however as the data on FOXO function in cancer are fragmentary and come from studies that focused on isolated aspects of cancer, especially for epithelial cancers. To clarify the role of FOXOs in epithelial cancer progression we characterized the effects of inducible FOXO activation and loss in a mouse model of metastatic invasive lobular carcinoma. Strikingly, either activation or loss of FOXO function suppresses tumor growth and metastasis. We show that the multitude of cellular processes critically affected by FOXO function including proliferation, survival, redox homeostasis and PI3K-signaling need to be carefully balanced for tumor cells to thrive.
ORGANISM(S): Mus musculus
PROVIDER: GSE108842 | GEO | 2018/02/11
REPOSITORIES: GEO
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