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Transcription profiling of uteruses from Alpk:APfCD-1 mice treated with arachis oil (AO) vehicle, 17beta-estradiol (E2), diethylstilbestrol (DES), or genistein (GEN) to study the effects of E2, GEN, and DES on gene transcription.

ABSTRACT: Three independent replicates of 4 groups of immature (19/20 days of age) Alpk:APfCD-1 mice were treated with arachis oil (AO) vehicle, 2.5ug/kg 17beta-estradiol (E2), 2ug/kg diethylstilbestrol (DES), or 50mg/kg genistein (GEN), via 3 daily subcutaneous injection, and sacrificed 72hr after initial dose.

ORGANISM(S): Mus musculus

SUBMITTER: Fei Ling Lim

PROVIDER: E-GEOD-1839 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The need to decide if all estrogens are intrinsically similar.

Moggs Jonathan G JG Ashby John J Tinwell Helen H Lim Fei Ling FL Moore David J DJ Kimber Ian I Orphanides George G

Environmental health perspectives 20040801 11

We used gene expression profiling to investigate whether the molecular effects induced by estrogens of different provenance are intrinsically similar. In this article we show that the physiologic estrogen 17-beta-estradiol, the phytoestrogen genistein, and the synthetic estrogen diethylstilbestrol alter the expression of the same 179 genes in the intact immature mouse uterus under conditions where each chemical has produced an equivalent gravimetric and histologic uterotrophic effect, using the ...[more]

PMID: 15289156

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