Unknown,Transcriptomics,Genomics,Proteomics

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BAC CGH array profiling using Phi29-amplified microdissected samples


ABSTRACT: Details of the experiment are available within the Nucleic Acid Research, 2004 manuscript "Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH", by Cardoso J. et al.

ORGANISM(S): Homo sapiens

SUBMITTER: Hans Morreau 

PROVIDER: E-GEOD-1841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH.

Cardoso Joana J   Molenaar Lia L   de Menezes Renée X RX   Rosenberg Carla C   Morreau Hans H   Möslein Gabriela G   Fodde Riccardo R   Boer Judith M JM  

Nucleic acids research 20041028 19


Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with small but clinically relevant tumor areas may pass undetected due to intra-tumor heterogeneity and/or the presence of contaminating normal cells. Here, we show that the combination of laser capture microdissection, phi29 DNA polymerase-mediated isothermal genomic DNA amplification, and array CGH allow  ...[more]

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