Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hans Morreau
PROVIDER: E-GEOD-1841 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cardoso Joana J Molenaar Lia L de Menezes Renée X RX Rosenberg Carla C Morreau Hans H Möslein Gabriela G Fodde Riccardo R Boer Judith M JM
Nucleic acids research 20041028 19
Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with small but clinically relevant tumor areas may pass undetected due to intra-tumor heterogeneity and/or the presence of contaminating normal cells. Here, we show that the combination of laser capture microdissection, phi29 DNA polymerase-mediated isothermal genomic DNA amplification, and array CGH allow ...[more]