Dataset Information

Proteomic profiling of colorectal adenomas

ABSTRACT: Colorectal adenomas are cancer precursor lesions of the large bowel. In these preinvasive lesions, a vast array of genomic and epigenomic changes have been detailed, but the consequence of these molecular alterations on the effectors of biological function (proteins) has not been comprehensively explored.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon

SUBMITTER: Anuli Uzozie

LAB HEAD: PD Dr. Giancarlo Marra

PROVIDER: PXD000445 | Pride | 2014-04-03

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20110718_002_Exp1_OGE01.mgf	Mgf
	20110718_002_Exp1_OGE01.raw	Raw
	20110718_003_Exp1_OGE02.mgf	Mgf
	20110718_003_Exp1_OGE02.raw	Raw
	20110718_004_Exp1_OGE03.mgf	Mgf

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Publications

Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.

Uzozie Anuli A Nanni Paolo P Staiano Teresa T Grossmann Jonas J Barkow-Oesterreicher Simon S Shay Jerry W JW Tiwari Amit A Buffoli Federico F Laczko Endre E Marra Giancarlo G

Molecular & cellular proteomics : MCP 20140224 5

Colorectal adenomas are cancer precursor lesions of the large bowel. A multitude of genomic and epigenomic changes have been documented in these preinvasive lesions, but their impact on the protein effectors of biological function has not been comprehensively explored. Using shotgun quantitative MS, we exhaustively investigated the proteome of 30 colorectal adenomas and paired samples of normal mucosa. Total protein extracts were prepared from these tissues (prospectively collected during colono ...[more]

PMID: 24567419

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