Genome wide DNA Methylation Study in Cornelia de Lange Syndrome
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: IAN KRANTZ
PROVIDER: E-GEOD-18458 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide DNA methylation analysis in cohesin mutant human cell lines.
Liu Jinglan J Zhang Zhe Z Bando Masashige M Itoh Takehiko T Deardorff Matthew A MA Li Jennifer R JR Clark Dinah D Kaur Maninder M Tatsuro Kondo K Kline Antonie D AD Chang Celia C Vega Hugo H Jackson Laird G LG Spinner Nancy B NB Shirahige Katsuhiko K Krantz Ian D ID
Nucleic acids research 20100506 17
The cohesin complex has recently been shown to be a key regulator of eukaryotic gene expression, although the mechanisms by which it exerts its effects are poorly understood. We have undertaken a genome-wide analysis of DNA methylation in cohesin-deficient cell lines from probands with Cornelia de Lange syndrome (CdLS). Heterozygous mutations in NIPBL, SMC1A and SMC3 genes account for ∼65% of individuals with CdLS. SMC1A and SMC3 are subunits of the cohesin complex that controls sister chromatid ...[more]
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