IDH1 mutation defines methylation class and survival in human glioma

ABSTRACT: Astrocytoma, oligodendroglioma, oligoastrocytoma, and ependymoma are the main histologic subtypes of glioma. The molecular character of these subtypes has profound implications for understanding their causes and treatment. We describe the epigenetic landscape of these tumor types using novel DNA methylation profiling tools. There is a robust association of methylation profile with tumor histology and IDH1 mutation status. Furthermore, tumors with IDH1 mutation independently predict a tumor hypermethylator phenotype, histology, TP53 mutation status, patient age, and survival. Integrating tumor epigenetic and genetic alterations, this work provides a critical step toward better defining the somatic nature of glioma which will have great potential to impact clinical approaches to disease. T

ORGANISM(S): Homo sapiens

SUBMITTER: Brock Christensen 

PROVIDER: E-GEOD-20395 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress