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Mouse cardiac tissues treated with doxorubicin and DMNQ

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE17823: Mouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 15mg/kg doxorubicin GSE17826: Mouse cardiac tissue: Vehicle treated control vs. 15mg/kg doxorubicin GSE17830: Mouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 25mg/kg DMNQ GSE17915: Mouse cardiac tissue: Vehicle treated control vs. 25mg/kg DMNQ Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Amy Pointon

PROVIDER: E-GEOD-18459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

Pointon Amy V AV Walker Tracy M TM Phillips Kate M KM Luo Jinli J Riley Joan J Zhang Shu-Dong SD Parry Joel D JD Lyon Jonathan J JJ Marczylo Emma L EL Gant Timothy W TW

PloS one 20100915 9

<h4>Background</h4>Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound due to its low redox potential. Here we used genomic and chemical systems approaches in vivo to investigate the mechanisms of doxorubicin cardiotoxicity, and specifically test the hy ...[more]

PMID: 20856801

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Mouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 25mg/kg DMNQ

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