Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Amy Pointon
PROVIDER: E-GEOD-17830 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20100915 9
<h4>Background</h4>Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound due to its low redox potential. Here we used genomic and chemical systems approaches in vivo to investigate the mechanisms of doxorubicin cardiotoxicity, and specifically test the hy ...[more]