Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Veena Valsakumar
PROVIDER: E-GEOD-18488 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Mingguang M Petteys Brian J BJ McClure Julie M JM Valsakumar Veena V Bekiranov Stefan S Frank Elizabeth L EL Smith Jeffrey S JS
Molecular and cellular biology 20100503 13
Genes encoding thiamine biosynthesis enzymes in microorganisms are tightly regulated such that low environmental thiamine concentrations activate transcription and high concentrations are repressive. We have determined that multiple thiamine (THI) genes in Saccharomyces cerevisiae are also regulated by the intracellular NAD(+) concentration via the NAD(+)-dependent histone deacetylase (HDAC) Hst1 and, to a lesser extent, Sir2. Both of these HDACs associate with a distal region of the affected TH ...[more]