Unknown,Transcriptomics,Genomics,Proteomics

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Identification of the Early VIP Transriptome and its Associated Interactome in Resting and Activated Murine CD4 T Cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE18524: Identification of the Early VIP Transriptome and its Associated Interactome in Resting Murine CD4 T Cells GSE18525: Identification of the Early VIP Transriptome and its Associated Interactome in Activated Murine CD4 T Cells Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Yulia Dementieva 

PROVIDER: E-GEOD-18526 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of the early VIP-regulated transcriptome and its associated, interactome in resting and activated murine CD4 T cells.

Dorsam Sheri Tinnell ST   Vomhof-Dekrey Emilie E   Hermann Rebecca J RJ   Haring Jodie S JS   Van der Steen Travis T   Wilkerson Erich E   Boskovic Goran G   Denvir James J   Dementieva Yulia Y   Primerano Donald D   Dorsam Glenn Paul GP  

Molecular immunology 20100201 6

More than 40 years after the discovery of vasoactive intestinal peptide (VIP), its transcriptome in the immune system has still not been completely elucidated. In an attempt to understand the biological role of this neuropeptide in immunity, we chose CD4 T cells as a cellular system. Agilent Mouse Whole Genome microarrays were hybridized with fluorescently labeled total RNA isolated from resting CD4 T cells cultured +/-10(-7)M VIP for 5h or PMA/ionomycin activated CD4 T cells cultured +/-10(-7)M  ...[more]

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