Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Analysis of human neurotrophins and receptors in bone marrow stromal cells (BMSC) treated with NGF or BDNF

ABSTRACT: BMSC gene expression profiling was completed to examine the baseline neurotrophin and receptor gene expression in BMSC and to evaulate changes in gene expression in response to NGF or BDNF stimulation In the study, primary BMSC were treated with recombinant human NGF or BDNF for 24 hours. Following treatment, RNA isolated from the BMSC were analyzed using the Human Neurotrophin and Receptor Gene Array HS-018

ORGANISM(S): Homo sapiens

SUBMITTER: Stephanie Rellick

PROVIDER: E-GEOD-18537 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway.

Rezaee Fariba F Rellick Stephanie L SL Piedimonte Giovanni G Akers Stephen M SM O'Leary Heather A HA Martin Karen K Craig Michael D MD Gibson Laura F LF

PloS one 20100315 3

<h4>Background</h4>The host's response to infection is characterized by altered levels of neurotrophins and an influx of inflammatory cells to sites of injured tissue. Progenitor cells that give rise to the differentiated cellular mediators of inflammation are derived from bone marrow progenitor cells where their development is regulated, in part, by cues from bone marrow stromal cells (BMSC). As such, alteration of BMSC function in response to elevated systemic mediators has the potential to al ...[more]

PMID: 20300619

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Dataset Information

Analysis of human neurotrophins and receptors in bone marrow stromal cells (BMSC) treated with NGF or BDNF

Publications

Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway.

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