Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Analysis of extracellular matrix and adhesion molecules expression in ALL cell line

ABSTRACT: The acute lymphoblastic leukemia cells lines JM-1, REH, Nalm-27, and SUP-B15 were analyzed for baseline expression of extacellular matrix and adhesion molecules using a pathway focused cDNA microarray (SABiosciences). RNA isolated from the ALL cell lines JM-1, REH, Nalm-27, and SUP-B15 was analyzed using the Extracellular Matrix and Adhesion Molecules Oligo GEArray (SABIosciences).

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Akers

PROVIDER: E-GEOD-18516 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers.

Akers Stephen M SM O'Leary Heather A HA Minnear Fred L FL Craig Michael D MD Vos Jeffrey A JA Coad James E JE Gibson Laura F LF

Experimental hematology 20100512 9

<h4>Objective</h4>Infiltration of the central nervous system (CNS) by leukemia is a problematic disease manifestation of acute lymphoblastic leukemia (ALL). The mechanisms by which leukocytes interact with human brain-derived microvasculature endothelial cells (HBMEC) and enter the CNS are largely derived from models of inflammation. However, our data indicate that ALL cells do not elicit an inflammatory phenotype by HBMEC. Our current investigation focuses on the contribution of the unique coex ...[more]

PMID: 20470859

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Dataset Information

Analysis of extracellular matrix and adhesion molecules expression in ALL cell line

Publications

VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers.

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