Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Alexander Brodsky
PROVIDER: E-GEOD-18592 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular endocrinology (Baltimore, Md.) 20100414 6
Posttranscriptional regulation may enhance or inhibit estrogen transcriptional control to promote proliferation of breast cancer cells. To understand how transcriptome and translational responses coordinate to drive proliferation, we determined estrogen's global and specific effects on translation regulation by comparing the genome-wide profiles of total mRNA, polysome-associated mRNA, and monosome-associated mRNAs in MCF-7 cells after stimulation by 1 h of 10 nm 17beta-estradiol (E2). We observ ...[more]