Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Stephen Taylor
PROVIDER: E-GEOD-18720 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kassouf Mira T MT Hughes Jim R JR Taylor Stephen S McGowan Simon J SJ Soneji Shamit S Green Angela L AL Vyas Paresh P Porcher Catherine C
Genome research 20100621 8
Coordination of cellular processes through the establishment of tissue-specific gene expression programs is essential for lineage maturation. The basic helix-loop-helix hemopoietic transcriptional regulator TAL1 (formerly SCL) is required for terminal differentiation of red blood cells. To gain insight into TAL1 function and mechanisms of action in erythropoiesis, we performed ChIP-sequencing and gene expression analyses from primary fetal liver erythroid cells. We show that TAL1 coordinates exp ...[more]