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Unknown,Transcriptomics,Genomics,Proteomics

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MRNA profiling in rectus abdominis muscle from patients with upper GI cancer

ABSTRACT: Rectus abdominis muscle biopsies were obtained from 65 upper gastrointestinal (UGI) cancer patients during open surgery and RNA profiling was performed on a subset of this cohort (n=21) using the Affymetrix U133+2 platform with the aim of identifying biomarkers of cancer related muscle wasting. N = 21 (18 UGI cancer; 3 non cancer surgery)

ORGANISM(S): Homo sapiens

SUBMITTER: Iain Gallagher

PROVIDER: E-GEOD-18832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia.

Stephens Nathan A NA Gallagher Iain J IJ Rooyackers Olav O Skipworth Richard J RJ Tan Ben H BH Marstrand Troels T Ross James A JA Guttridge Denis C DC Lundell Lars L Fearon Kenneth C KC Timmons James A JA

Genome medicine 20100115 1

<h4>Background</h4>Cancer cachexia is a multi-organ tissue wasting syndrome that contributes to morbidity and mortality in many cancer patients. Skeletal muscle loss represents an established key feature yet there is no molecular understanding of the disease process. In fact, the postulated molecular regulators of cancer cachexia originate largely from pre-clinical models and it is unclear how these translate to the clinical environment.<h4>Methods</h4>Rectus abdominis muscle biopsies were obtai ...[more]

PMID: 20193046

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mRNA profiling in rectus abdominis muscle from patients with upper GI cancer

Project description:Rectus abdominis muscle biopsies were obtained from 65 upper gastrointestinal (UGI) cancer patients during open surgery and RNA profiling was performed on a subset of this cohort (n=21) using the Affymetrix U133+2 platform with the aim of identifying biomarkers of cancer related muscle wasting.

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Genome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

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