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Transcription profiling of Rhesus monkey extraocular muscle and its layers

ABSTRACT: Rhesus monkey extraocular muscle. Data set includes: (a) whole medial and lateral rectus muscle and (b) global and orbital muscle layers separately microdissected using a Leica LSM. All samples were expression profiled here using the Affymetrix human U133 A&B arrays. Data form part of publication: Investigative Ophthalmology and Visual Science 45 (in press), 2004.

ORGANISM(S): Macaca mulatta

SUBMITTER: Sangeeta Khanna

PROVIDER: E-GEOD-907 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide transcriptional profiles are consistent with functional specialization of the extraocular muscle layers.

Khanna Sangeeta S Cheng Georgiana G Gong Bendi B Mustari Michael J MJ Porter John D JD

Investigative ophthalmology & visual science 20040901 9

<h4>Purpose</h4>Compartmentalization of the extraocular muscles into well-defined orbital and global layers is highly conserved. Recently, the active pulley hypothesis correlated the anatomic properties of orbital-global muscle layers with layer-specific division of labor. Microarray technology was used to identify muscle-layer-specific transcriptional profiles and, thereby, extend understanding of the structure-function characteristics of extraocular muscle layers.<h4>Methods</h4>Laser capture ...[more]

PMID: 15326121

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